… protein Rai is a negative regulator of T cell receptor signaling … hyperactive phenotype of T
cells in autoimmune diseases. … suppresses TCR signaling and T cell activation, together with …

… in the mouse experimental autoimmune encephalomyelitis (EAE… identify Rai as a negative
regulator of this inhibitory circuitry. … in T cells Rai limits antigen receptor signaling by impairing …

… negative regulators of G protein function and RhoG. ARHGDIG or Rho-GDP-dissociation
inhibitor-3 inhibits … against immunological disorders such as autoimmune diseases and other …

… activity of Rai as a negative regulator of TCR and BCR signaling, it has been observed that
… differentiation and autoimmunity The ability of Rai to fine-tune the antigen receptor signaling …

… against self-antigens and prevent autoimmunity. One … PD-1 in inhibiting T cell antigen
receptor (TCR) signaling, yet via distinct … Given the negative regulation of CD8 T cells by an LPA-…

… B cell activation and the aberrant signaling downstream of … A diverse antigen receptor
repertoire is generated by the unique … It is established that PTPN22 is a negative regulator of SRC-…

… We have previously shown in the experimental autoimmune … that negatively regulates T cell
activation and Th17 cell … /TLR signaling pathway, the negative regulation of HIF-1α function, …

… act as negative regulators of inflammation, restoring balance after prolonged inflammatory
activation. … Teriflunomide, a dihydroorotate dehydrogenase inhibitor that limits T cell activation …

… , whose signaling can activate or inhibit leukocyte function … monoclonal antibodies reduces
T FH - and T PH -driven plasma cell … B cell activation in inflammatory autoimmune disorders. …

… critical for the expansion of autoimmune and CLL cells. This … molecule inhibitors of B cell
antigen receptor (BCR) signalling … Thus, BIRC3 is a negative regulator of the canonical NF-κB …